直接眉提升切口瘢痕最小化的现代理念与技术

Abstract 原文摘要

Background : Despite the rise of endoscopic approaches, the direct brow lift remains one of the most effective procedures for correcting brow ptosis for both functional and cosmetic indications. It continues to offer superior control when correcting brow shape, height, and asymmetry. However, visible scarring remains a concern. This systematic review was conducted to synthesize recent evidence on strategies that minimize visible scarring in direct brow lift surgery. Methods : A systematic literature search was performed to retrieve English-language publications from the past decade, discussing scar-minimization strategies in direct brow lift. A total of 124 records were identified through database searches in Ovid MEDLINE and Embase. Records were screened manually according to predetermined criteria, and those not in English, not addressing scarring, or not focused on direct brow lift were excluded. After this process, ten publications were included in the final qualitative synthesis. Results : The qualitative synthesis of all included publications (together comprising data on approximately 900 patients) revealed several strategies for scar minimization. (1) Incision beveling: A shallow cranially directed bevel between 20° and 45° preserves brow hair follicles and allows hair regrowth through the scar, providing natural camouflage. (2) Undermining: Gentle subcutaneous undermining in a limited 1–2 cm field, while preserving subcutaneous fat, allows tension-free advancement and maintains brow volume. (3) Periosteal suspension: Anchoring the mobilized brow flap to the frontal periosteum redistributes tension away from the dermal closure, maintaining elevation and improving scar quality. (4) Layered closure: Two- or three-layered wound closure with deep dermal anchoring and fine everting skin sutures minimizes dermal traction and scar widening. (5) Adjunctive measures: Evidence for topical silicone gel was inconclusive, whereas postoperative laser therapy and perioperative neuromodulator use demonstrated improved scar appearance. Across studies, outcomes were consistent, with high patient satisfaction, inconspicuous scars in over 85% of cases, and low complication or revision rates. Conclusions : Direct brow lift has historically been criticized for conspicuous scarring, contributing to the popularity of endoscopic techniques. Nevertheless, the traditional direct brow lift remains a fundamental skill in the oculofacial plastic surgeon’s armamentarium, offering unmatched accuracy in brow repositioning, reliability, and symmetry. Contemporary evidence demonstrates refinements that can markedly minimize scar visibility. This systematic review and qualitative synthesis allow us to continue to refine and improve our techniques to minimize scarring in direct brow lift to the benefit of our patients.

Keywords: direct brow lift、oculofacial plastic surgery、scar minimization、scar visibility、brow ptosis、eyebrow lift

1. Introduction

The position and contour of the eyebrows play an important role in the visual field [ 1 ], social settings [ 2 ], and facial esthetics [ 3 ]. Brow ptosis, whether age-related, secondary to trauma, or due to facial nerve dysfunction, can have negative implications for quality of life [ 4 ]. Over the past century, numerous surgical techniques have been developed for the correction of brow position and contour [ 5 ]. These include endoscopic, coronal, pretrichial, and transblepharoplasty approaches. Nevertheless, the direct brow lift remains the most powerful method for brow lift, offering accurate control of both brow height, shape, and contour [ 6 ].

Despite its precision and effectiveness, the direct brow lift continues to be limited by the potential for visible postoperative scarring. Because the incision is placed in an exposed area immediately above the brow, even a fine linear scar can be noticeable, particularly in patients with thin or sparse brow hair. This makes patient selection and preoperative counseling particularly important. Thick sebaceous brow skin, often encountered in male patients, may increase the risk of a more visible scar or contour irregularity, whereas thin or thinning brow hair may reduce the ability of the brow to camouflage the incision. These factors should therefore be considered when selecting patients, planning incision placement, and counseling patients about scar visibility. Variations in individual healing characteristics and skin type further influence scar visibility. These esthetic concerns have significant medicolegal implications: brow lift surgery ranks among the most commonly litigated procedures in oculoplastic practice, with excessive or disfiguring scarring cited as the most frequent cause of malpractice claims [ 7 ]. Such outcomes can lead to patient dissatisfaction, revision requests, and legal disputes, highlighting the importance of surgical technique and thorough preoperative counseling. Although alternative approaches such as endoscopic and pretrichial brow lifts have gained popularity for their concealed incisions, the direct brow lift remains indispensable in cases requiring precise control of brow shape, symmetry, and elevation. The challenge, therefore, lies not necessarily in the indication for surgery but in refining the technique to achieve consistent, durable, and esthetically subtle results while minimizing scar conspicuity.

This systematic literature review consolidates contemporary evidence on surgical and adjunctive strategies intended to minimize scarring in direct brow lift surgery. The aim is to identify reproducible principles that may help surgeons achieve less conspicuous scars while preserving functional and esthetic control of brow position.

2. Methods

A systematic literature search was conducted in Ovid MEDLINE and Embase on 13 March 2025 by a medical librarian experienced in systematic searching. The search combined terms for brow lifting and direct brow lift (including brow lift, eyebrow lift, brow ptosis, and brow incision) with scar-related terms (including scar, cicatrix, and keloid). The search was limited to English-language publications from the preceding 10 years. The complete search strategy is provided as Supplementary Materials (Supplementary Materials Table S1) . Studies were eligible if they focused on the direct brow lift and reported scar outcomes or technical measures relevant to scar visibility, including incision design, dissection plane, fixation or tension reduction, wound closure, or adjunctive scar management. Prospective and retrospective cohorts, randomized trials, surveys, and technique papers were considered. Studies were excluded if they did not address scarring, focused primarily on endoscopic, temporal, coronal, or other nondirect approaches without separate direct brow lift data, or were not published in English. The initial search retrieved 124 records. Two reviewers independently screened all titles and abstracts; this was followed by full-text assessment of potentially eligible studies. Records were excluded if they (a) did not primarily address scar minimization or scar outcomes following brow lift procedures ( n = 87), (b) focused on endoscopic, temporal, or coronal approaches as opposed to the direct brow lift technique ( n = 26), or (c) were not published in English ( n = 3). Reference lists of all included papers were manually searched to identify additional eligible studies not captured in the electronic search. Subsequently, ten publications remained eligible and were included in the final qualitative synthesis ( Figure 1 ). These comprised a survey of surgeons, prospective cohort studies, retrospective cohort studies in patients with facial palsy, a randomized controlled trial comparing silicone gel with placebo, technique and position papers, and additional prospective cohorts and retrospective analyses addressing scar-minimization strategies specific to direct brow lift surgery. During the preparation of this manuscript, the authors used an AI-based language model (ChatGPT, version 5.0 Pro) to assist with English-language editing and grammatical refinement. The authors have reviewed and edited the output and take full responsibility for the content of this publication.

Figure 1 A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram of study identification, inclusion, and exclusion.

3. Results

Ten publications met the inclusion criteria: prospective and retrospective cohorts or analyses, randomized trials, technique-oriented reports, and one survey of surgeons. Patient-based studies ranged from single-case technical reports to cohorts of 496 patients; the surgeon survey included 276 respondents. Across studies, the most frequent scar-minimizing themes were incision beveling parallel to brow follicles, limited undermining with preservation of subcutaneous volume, deeper fixation to reduce closure tension, layered closure with skin-edge eversion, and selected adjuncts such as neuromodulators or laser therapy ( Figure 2 ). Quantitative scar-related reporting was inconsistent. Shu et al. reported “inconspicuous scars” in 428 of 432 followed patients [ 8 ]; Pascali et al. reported “statistically significant” brow elevation in 98% of patients with visible scarring in 2 of 50 cases [ 9 ]; Butler et al. reported a mean Manchester Scar Scale score of 8.6/28, no postoperative forehead paraesthesia or brow alopecia, and “excellent” or “good” brow height in 85% of brows [ 10 ]; Fakih-Gomez et al. reported symmetrical brow positioning in 97.8% of patients with generally “inconspicuous” scarring [ 11 ]; and Feinendegen et al. reported “very good” or “good” outcomes in 16 of 18 patients. Cadet et al. found no significant advantage of topical silicone gel over placebo [ 12 ], whereas Tenzel et al. found patient-rated improvement after serial non-ablative Nd:YAG laser sessions [ 13 ]. Patient selection was variably reported across the included studies. Some studies defined cohorts according to indication or population subgroup, including facial palsy-related brow ptosis, Asian women with lateral brow ptosis and upper eyelid hooding, men undergoing direct brow lift with upper blepharoplasty, and patients enrolled for postoperative scar treatment. However, few studies explicitly selected or stratified patients according to scar-relevant anatomical factors such as brow skin thickness, brow hair density, thinning lateral brow hair, sebaceous skin quality, or predisposition to hypertrophic scarring. Smoking was reported as a relevant negative factor in one study, but systematic reporting of patient-selection criteria related to scar camouflage was generally limited. Study-level details, including reported incision extent and associated refinements, are summarized in Table 1 .

Figure 2 Strategies repeatedly identified across the reviewed literature for achieving inconspicuous scarring. A shallow cranially directed bevel between 20° and 45° preserves hair follicles and allows regrowth through the incision line, providing natural camouflage (A). Gentle subcutaneous undermining in a limited 1–2 cm field, while preserving subcutaneous fat, facilitates tension-free advancement and maintains brow volume (B). Periosteal suspension redistributes tension away from the dermal closure, maintaining brow elevation and preventing scar widening (C), followed by layered closure with fine everting sutures for optimal dermal alignment (D). Adjunctive perioperative botulinum toxin injections reduce dynamic muscle tension during healing, supporting improved scar quality (E). Parts of this figure were adapted and modified with inspiration from Fakih-Gomez et al., Feinendegen et al., and Abraham et al. Illustration: Kristin Skårdal.Table 1 Summary of included publications evaluating scar-minimization strategies in direct brow lift surgery. Incision extent is described as reported by the included publications; when lateral versus full-length extent was not explicitly quantified, this is indicated as individualized or NR (not reported). Abbreviations: OOM, orbicularis oculi muscle; Nd: YAG, neodymium-doped yttrium aluminum garnet; RCT, randomized controlled trial.

In summary, we found the following concepts to be repeated in the majority of our included full texts: (1) incision beveling, (2) gentle undermining, (3) periosteal suspension, (4) layered suturing with skin-edge eversion during final skin sutures, and (5) the use of perioperative neuromodulators ( Figure 2 ).

4. Discussion

By describing the excision of small, symmetrical ellipses of skin immediately above each brow to achieve elevation, Dr. Raymond Passot is credited with popularizing the direct brow lift in the 1930s [ 18 ]. Since then, numerous modifications and alternative approaches, including endoscopic, coronal, pretrichial, and transblepharoplasty techniques, have been developed to refine outcomes and reduce morbidity [ 5 ]. Despite these advances, the direct brow lift remains useful because it offers predictable control over brow height, shape, and symmetry [ 10 ]. However, the visible incision makes scar management central to patient selection, counseling, and operative planning [ 12 ].

Preoperative marking deserves specific attention because the shape and extent of excision influence both brow contour and scar concealment. The reviewed techniques vary from classical elliptical or fusiform suprabrow excisions, often with the maximal vertical height positioned near the lateral third of the brow arch, to more laterally weighted markings designed primarily to elevate the lateral brow tail. The medial and lateral limits of the excision are also important. Medial brow skin is often thicker and may be less forgiving if over-resected, whereas lateral brow hair may be thinner and provide less reliable camouflage. Therefore, the marking should be individualized according to the vector of brow ptosis, desired brow shape, brow hair density, skin thickness, sex-associated brow esthetics, and the need for either global or predominantly lateral elevation.

Incision design is one of the most consistently reported determinants of scar concealment. The reviewed studies describe either full-length supraciliary excisions when global elevation or asymmetry correction is required, or segmental and lateral designs when the deformity is mainly temporal or lateral. Regardless of extent, the incision is generally placed at or within the superior brow margin and beveled parallel to hair follicles. Feinendegen et al. used a 20° cranially beveled incision just below the superior brow margin to include the upper rows of brow hair [ 17 ]. In a subsequent publication, the authors further elaborated on the “flat incision technique”, showing that a shallow, cranially directed bevel increases the dermal surface area available for wound healing and enhances scar quality [ 15 ]. Similarly, Pelle-Ceravolo and Angelini employed a 30° bevel and limited undermining, confirming that shallow incision angles minimize hair bulb transection and improve scar concealment [ 16 ]. Together, these studies confirm that shallow cranially directed beveling between 20° and 45° remains an important strategy for minimizing scar visibility in direct brow lift surgery. Incision extent and contour should also reflect patient anatomy and sex-associated esthetic goals. In men, a lower and flatter brow contour is often desirable, and denser brow hair may permit a longer supraciliary incision to be camouflaged, as illustrated by Pascali et al. [ 9 ]. In women, especially when the goal is restoration of a lateral peak rather than global elevation, segmental or lateral designs may reduce the risk of over-elevating the medial brow. Shu et al. further showed that in Asian women, who may have higher baseline brows, wider upper eyelids, and more upper eyelid fullness, a combined supra-brow and infra-brow design can address lateral hooding while avoiding excessive brow elevation [ 8 ]. These observations support individualized incision planning rather than a uniform lateral or full-length approach.

Gentle subcutaneous undermining was another consistently emphasized element across the reviewed studies. The rationale behind undermining is to free the brow flap from the underlying orbicularis and frontalis fascia to reduce the risk of brow ptosis relapse, to allow tension-free advancement, and to prevent traction and tension on the final wound (which would cause excessive scarring). Most authors describe subdermal undermining in a narrow field, typically 1–2 cm cranially and caudally from the incision, in a plane superficial to the frontalis and orbicularis fascia [ 9 , 15 , 16 , 17 ]. Feinendegen et al. performed subdermal undermining in both directions within this limited range to achieve smooth contouring [ 15 , 17 ]. Similarly, Pascali et al. restricted dissection to approximately 7–10 mm below the brow and 2–3 mm above it [ 9 ]. Pelle-Ceravolo and Angelini supported this conservative approach, performing limited subdermal undermining only to relieve tension on closure [ 16 ]. Interestingly, Fakih-Gomez et al. describe a more excessive deep-plane undermining performed not only in the subcutaneous plane, but also beneath the subfrontalis fascia (via transection of orbicularis oculi muscle) until it reaches the retro-orbicularis fat and downward until reaching the orbital retaining ligament region [ 11 ]. After all this release, the brow is suspended to the frontal periosteum by Vicryl sutures passed through the orbicularis muscle and the deep frontalis fascia [ 11 ]. Throughout the dissection, the subcutaneous fat is preserved to maintain brow volume and avoid contour deformities, a principle highlighted across several studies. Regardless of the extent of undermining, all studies emphasized the importance of not damaging the brow hair follicles during dissection. Similarly, hemostasis was also stressed.

Periosteal suspension aims to anchor the mobilized brow flap to the underlying frontal periosteum, thereby maintaining brow elevation and preventing scar widening caused by tension. It also transfers tension from the dermal closure to a deeper, more stable fixation point. When performed appropriately, periosteal suspension should be achieved without skin puckering. Butler and colleagues demonstrated that small transcutaneous punctures for periosteal fixation could provide stable support without added dissection or contour irregularity, yielding excellent scar and sensory outcomes in patients with facial palsy [ 10 ]. Fakih-Gomez et al. employed, following extensive undermining, a superior anchoring suture to the frontal periosteum by traversing through the frontalis muscle at the maximum point of elevation [ 11 ]. This was in addition to 3–5 suspending sutures passed in the same manner, but more inferiorly. Feinendegen et al. [ 15 , 17 ] and Pascali et al. [ 9 ] also incorporated periosteal sutures to distribute tension evenly across the flap while limiting closure stress. Periosteal suspension not only enhances longevity of elevation but also contributes to improved scar esthetics by reducing wound-edge traction. Across all reviewed studies, periosteal suspension was consistently identified as an effective strategy to ensure durable brow positioning and superior scar quality. A recent case series, published after the prespecified search date, extends this concept to retro-orbicularis oculi fat (ROOF) mobilization and superior fixation [ 19 ]. Murdock et al. reported 9 male patients undergoing bilateral direct brow lift with ROOF repositioning; mean brow-reflex distance improved from 5.17 to 11.76 mm, temporal hooding improved in all patients, and no revisions, frontalis paresis, or neural compromise were reported [ 19 ]. Although this study primarily addresses functional and contour outcomes rather than scar scoring, it highlights the intraoperative value of deeper soft-tissue support and volume repositioning, particularly in mature male patients.

Layered closure with skin-edge eversion is another recurring scar-minimizing principle. The purpose of a layered wound closure is to distribute tension evenly across the wound, minimize dermal traction, and achieve precise skin-edge apposition for fine, inconspicuous scars. Most authors describe a two- or three-layer closure beginning with deep dermal sutures followed by fine subcuticular or cutaneous sutures for accurate epidermal alignment [ 9 , 15 , 16 , 17 ]. Feinendegen et al. used deep 5-0 Maxon sutures grasping periosteum, combined with a continuous 7-0 Prolene skin suture [ 15 , 17 ]. Pelle-Ceravolo and Angelini emphasized skin-edge eversion and the use of fine nylon sutures to prevent track marks and scar depression [ 16 ]. Interestingly, Butler et al. describe counter-bevelling of the upper and lower incision lines so that, upon closure of the deep dermis, the wound edges are encouraged to pout [ 10 ]. However, this is in contrast to the beveling technique described above to preserve hair follicles. Overall, the reviewed evidence supports multilayered closure with careful tension distribution and skin-edge eversion in achieving imperceptible scars. This is also in line with established surgical practice.

Beyond refinements in surgical technique, adjunctive strategies to improve scar remodeling have also been explored. Cadet et al. conducted a randomized controlled trial comparing silicone gel to placebo following direct brow lift and found no statistically significant difference in scar appearance between the two groups, suggesting that topical silicone gel alone may have limited benefit [ 12 ]. Tenzel et al. demonstrated that postoperative use of non-ablative 1064 nm Nd:YAG laser enhanced scar appearance after direct brow lift [ 13 ]. The perioperative use of neuromodulators represents another increasingly recognized adjunct in optimizing scar outcomes [ 20 ]. The rationale lies in the ability of botulinum toxin to induce temporary chemodenervation of the frontalis, corrugator, procerus, and orbicularis oculi muscles, thereby reducing dynamic tension across the healing wound. Constant micromovement in the early postoperative phase has long been associated with widened or hypertrophic scars, and selective neuromodulation mitigates this by maintaining relative immobility during the critical period of collagen deposition and remodeling. Abraham et al. surveyed 276 surgeons and found that approximately 25% routinely administered neuromodulators two weeks before surgery and 45% continued treatment postoperatively, typically every three months, to sustain tension reduction during healing [ 14 ]. Fakih-Gomez et al. also incorporated preoperative botulinum toxin injections to the depressor supercilii and orbicularis oculi muscles, complementing mechanical tension release achieved through deep-plane dissection [ 11 ]. Similarly, Pelle-Ceravolo and Angelini injected 5 units of botulinum toxin into the frontalis muscle above the lateral two-thirds of each brow two to three days before surgery [ 16 ]. These findings mirror a broader trend in esthetic and reconstructive surgery, where neuromodulators are increasingly employed perioperatively to optimize scar outcomes following blepharoplasty, facelift, and resurfacing procedures [ 21 ]. Collectively, current evidence supports the judicious use of perioperative neuromodulators as a clinically effective adjunct to traditional scar-minimizing techniques in direct brow lift surgery.

An important limitation across the reviewed studies is the variability in how outcomes, particularly scar outcomes, are assessed. In many cases, results are described using subjective terms such as “minimal”, “inconspicuous”, or “imperceptible”, without clear definitions or standardized criteria. Objective characteristics such as scar width, depth, length, color, and location are only inconsistently reported, making it difficult to compare findings across studies. Similarly, validated scar assessment tools, such as the Vancouver Scar Scale or the Patient and Observer Scar Assessment Scale, are rarely used. Patient-reported outcomes are commonly included, but these are often limited to general satisfaction or cosmetic acceptability and are typically measured using non-standardized questionnaires. This lack of consistency introduces potential bias and limits the strength of conclusions that can be drawn from the existing literature.

A closer look at the included studies further illustrates this variability. Some authors incorporated objective measurements. For example, Pascali et al. used standardized photographic analysis to quantify brow position and combined this with both clinician and patient-based assessments [ 9 ]. Shu et al. similarly reported measurable periocular parameters, such as palpebral fissure height and eyebrow-to-eyelid distances, alongside complication rates and patient satisfaction [ 8 ]. In contrast, other studies relied more heavily on descriptive evaluations based on clinical photographs and overall impressions of scar visibility. A few studies attempted more structured assessments; for instance, Tenzel et al. used numerical rating scales and blinded photographic comparisons, but these still largely reflected perceived appearance rather than detailed scar morphology [ 13 ]. Across the literature, patient-reported outcomes were almost always included, yet the way they were collected and reported varied widely. Taken together, while many studies attempt to capture both objective and subjective outcomes, the lack of standardized, multidimensional assessment frameworks remains a key limitation.

In conclusion, contemporary refinements in direct brow lift surgery reflect a clear evolution toward techniques that balance functional precision with esthetic subtlety. The available evidence suggests that optimal scar outcomes are achieved through a combination of careful incision design, controlled tissue handling, tension redistribution, and thoughtful use of adjunctive therapies. At the same time, future research would benefit from more consistent and comprehensive outcome assessment, integrating both objective scar characteristics and validated patient-reported measures. Such standardization would allow more meaningful comparisons across studies and further refine best practices in this procedure.

解剖基础与手术要点

• 为什么直接眉提升仍被保留： 内窥镜、冠状、预发际与经睑成形术虽切口隐蔽，但直接眉提升对眉高度、形状与轮廓（尤其不对称矫正）的控制力仍较强，在需要精确塑形时难以替代；其代价是切口位于眉毛上方的暴露区。
• 切口设计的解剖前提： 切口一般置于上缘眉缘处或缘内，并 平行毛囊作浅角度颅侧斜面（20°–45°） ：Feinendegen 等用 20° 颅侧斜面以纳入上排眉毛，Pelle-Ceravolo 与 Angelini 采用 30°，共同理由是减少毛囊切断、让眉毛可穿过瘢痕生长以形成自然遮盖；其"平切口技术"还提出浅斜面可增加真皮接触面积以改善瘢痕质量。
• 范围个体化： 需整体提升或矫正不对称时可行全段眉上梭形切除（传统做法常将较高的垂直高度设计在眉弓外侧三分之一处）；以外侧/颞侧畸形为主时可行节段式或偏外侧设计。女性以恢复外侧眉峰为目标时，节段式/外侧设计有助于避免内侧眉被过度抬高；亚洲女性眉位较高、上睑饱满、存在外侧上睑遮盖，Shu 等采用眉上联合眉下设计以处理外侧遮盖而不致过度抬高。
• 有限皮下剥离： 多数作者在额肌与眼轮匝肌筋膜浅层、切口上下各约 1–2 cm 的狭窄范围内剥离，使眉瓣可无张力前移并降低闭合张力，同时保留皮下脂肪以维持眉区容积与轮廓；Pascali 等限制为眉下 7–10 mm、眉上 2–3 mm。Fakih-Gomez 等则描述更广泛的深平面剥离（皮下平面，并经额肌筋膜下切断眼轮匝肌，直达眶轮匝肌后脂肪，下达眶支持韧带区），并以 3–5 支缝线悬吊于额骨骨膜。
• 骨膜悬吊： 将已动员的眉瓣锚定于额骨骨膜，把张力从真皮闭合转移到更深、更稳定的固定点，以维持提升高度并降低瘢痕增宽风险；实施时应避免皮肤表面皱缩（puckering）。Butler 等采用经皮小穿刺点行骨膜固定，避免额外剥离与轮廓不规则。
• 分层关闭： 普遍采用 2–3 层关闭，先深真皮锚定（Feinendegen 等以 5-0 Maxon 抓持骨膜），再以精细皮内或皮肤缝线实现表皮精确对合（Prolene 7-0 连续缝合），并强调 皮肤缘外翻 以减少针轨痕与瘢痕凹陷；Pelle-Ceravolo 与 Angelini 强调用细尼龙线并使创缘外翻。Butler 等则描述对上下切口线作反向斜面，使深真皮关闭后创缘"唇状"外凸——此与前述保护毛囊的斜面技术形成对照。

临床定位与操作

• 患者选择与沟通： 原文强调直接眉提升的适应证本身并非问题所在，核心在于技术精修；术前标记应结合眉下垂向量、目标眉形、眉毛密度、皮肤厚度与性别相关美学需求个体化设计。皮肤较厚且皮脂腺丰富（常见于男性）者更易出现明显瘢痕或轮廓不规则；眉毛稀疏/变细者遮盖能力下降。
• 法医学背景： 原文指出眉提升术在眼整形领域属诉讼高发术式之一， 过度或明显瘢痕是最常见的 malpractice 索赔原因 之一——这使术前告知与文书记录尤为必要。
• 围手术期神经调节剂： 原理为暂时性化学失神经（额肌、皱眉肌、降眉内肌、眼轮匝肌）以降低愈合期动态张力；Abraham 等 276 名医师调查显示约 25% 常规术前 2 周给药、45% 术后继续（多每 3 个月一次）；Pelle-Ceravolo 与 Angelini 在术前 2–3 天于每侧眉外侧三分之二额肌注射 5 U；Fakih-Gomez 等术前注射降眉内肌与眼轮匝肌，配合深平面松解的机械性减张。
• 能量设备辅助： Tenzel 等报告术后多次非剥脱 1064 nm Nd:YAG 激光治疗后患者自评瘢痕外观改善（使用数字评分与盲法照片对比，但主要反映主观感知而非瘢痕形态学量化）。
• 硅凝胶证据不足： Cadet 等 RCT 比较硅凝胶与安慰剂，瘢痕外观无统计学差异，提示单用硅凝胶获益可能有限。
• 深部软组织松解的补充证据（检索截止日后发表）： 原文提及 Murdock 等病例系列，9 名男性行双侧直接眉提升并 ROOF（眶轮匝肌后脂肪）重置，眉反射距离平均由 5.17 mm 增至 11.76 mm，颞部遮盖均获改善，未报告需修复、额肌麻痹或神经功能受损；该研究主要关注功能与轮廓结局， 未对瘢痕进行评分 。

风险与局限

• 评估方法不统一（原文自述的核心局限）： 瘢痕结局多以"minimal/inconspicuous/imperceptible"等主观词语描述，缺乏明确定义；瘢痕宽度、深度、长度、颜色与位置等客观特征报告不一致；Vancouver Scar Scale、POSAS 等经过验证的量表罕用；患者报告结局虽普遍纳入，但多限于总体满意度或美容可接受性，且多采用非标准化问卷。部分研究使用标准化照片分析（Pascali 等）、客观测量指标（Shu 等报告睑裂高度、眉-眼距离），但整体仍缺乏标准化、多维度评估框架。
• 证据构成偏倚： 纳入研究以队列与技术报告为主，样本量从个案到 496 例不等，瘢痕相关定量报告"不一致"；医师调查报告（276 名）反映的是实践模式与偏好，并非患者报告结局。
• 患者特征分层不足： 仅少数研究按瘢痕相关解剖因素（眉皮肤厚度、眉毛密度等）选择或分层患者，而上述因素恰是瘢痕可见度的关键变量，削弱了结论的可推广性。
• 患者选择偏倚： 各研究的人群（如面瘫相关眉下垂、亚洲女性外侧眉下垂伴上睑遮盖、男性合并上睑成形术、术后瘢痕治疗人群）差异极大，难以互相比较。
• 结论解读边界： 原文提出的"组合运用切口设计、精细组织操作、张力重新分配与辅助治疗"是 方向性共识 ；具体对瘢痕可见度的改善幅度无法从现有异质证据中定量估计，临床仍应以个体解剖、偏好与充分知情同意为基础进行个体化决策。